Microvi, Nexilico, and UC Berkeley Awarded NIH Funding to Develop Platform to Predict Gut Microbiome Effect on Drug Efficacy and Toxicity
Microvi, Nexilico, and the University of California Berkeley have been awarded a grant from the National Center for Advancing Translational Sciences (NCATS) to develop a new computational solution for reliable and cost-effective prediction of gut microbiome-mediated drug metabolism and its effect on drug efficacy and toxicity.
The gut microbiome interacts with a range of therapeutics across indications, resulting in biotransformation of drugs into metabolites with altered disposition, efficacy, and toxicity. As a result, gut microbiome-mediated drug metabolism could lead to non-effective treatments as well as toxic side effects. Accordingly, it is now widely recognized that gut microbiome is a determining factor in drug metabolism and should be accounted for in attempts to improve drug development and treatment effectiveness.
In collaboration with University of California Berkeley and Microvi, Nexilico will develop this comprehensive in silico solution, supported by rigorous experimental validation, to reliably identify and characterize microbial metabolism of drugs. The proposed methods will increase the reliability of predictions to achieve the accuracy necessary for clinical and commercial use.
This project is designed to not only advance the current understanding of microbiome function in the context of drug-gut interactions but also inform strategies to help enhance public health and economic growth.
Shedding light on microbial metabolism of drugs can help reduce the cost and timeframe of drug development, increase drug development success rate, and develop more effective therapeutics and personalized treatment strategies. Additionally, this technology substantially increases the safety of drugs by predicting the mechanisms of efficacy and toxicity as they may differ from individual to individual.
About Nexilico
Nexilico is a life sciences and biotechnology company that employs the power of computational and systems biology to address challenging problems in medicine and biotechnology. As a pioneer in advanced in silico microbiome technologies, Nexilico advances scientific understanding about the role of microbiomes in health and disease and leverages that information to develop novel microbiome-based technologies. Learn more at www.nexilico.com
About Microvi
Microvi is an applied biotechnology company based in the San Francisco Bay Area that develops and commercializes next-generation biosolutions to address critical challenges in climate change, water, energy, waste, health, and environmental sustainability. Powered by its proprietary MicroNiche Engineering™ (MNE) platform, Microvi delivers proven, high-performance biosolutions worldwide – reducing greenhouse gas emissions and waste while increasing productivity and cost-efficiency for its customers. Microvi’s scaleable biosolutions are deployed globally across diverse sectors, providing disruptive economic value for industry partners and ultimately contributing to a cleaner environment and healthier communities. Learn more at Microvi Biotech.
About the National Center for Advancing Translational Sciences
The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) was officially established in fiscal year 2012 to transform the translational science process so that new treatments and cures for disease can be delivered to patients faster. NCATS, one of 27 Institutes and Centers (ICs) at NIH, strives to develop innovations to reduce, remove or bypass costly and time-consuming bottlenecks in the translational research pipeline in an effort to speed the delivery of new drugs, diagnostics and medical devices to patients. Learn more at https://ncats.nih.gov/
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